TGF beta 2/TGFB2 蛋白, Human|种属:Human|重组蛋白,TGF beta 2/TGFB2 蛋白, Human,Greater than 95% as determined by reducing SDS-PAGE.
产品编号:西域-HYP7119| MDL NO:Human
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用,
描述 | Transforming growth factor-beta 2 (TGF-β2), an extracellular glycosylated protein, is a member of the TGF-β superfamily. TGFβ2 controls key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2). TGF-β2 is an immune suppressor involved in the development of immune tolerance, and also regulates embryonic development. TGF beta 2/TGFB2 Protein, Human is produced in HEK293 cells, and consists of 112 amino acids (A303-S414). |
---|---|
研究背景 | In mammals, three different isoforms of TGF-β are described (TGF-β1, TGF-β2 and TGF-β3; transforming growth factor beta) to regulate apoptosis, proliferation, differentiation, migration and invasion processes utilising overlapping but not redundant mechanisms. All three isoforms are expressed in the liver, but their expression is differentially distributed among liver cell types. TGF-β2 expression in different liver cell types and is also associated with developmental defects and fibrotic diseases in mice. |
体外研究 (In Vitro) | Recombinant human TGF-β2 (1.25, 2.5, 5, 10, and 20 ng/mL; for 24 h) increases extracellular matrix (ECM) protein synthesis and secretion in optic nerve head (ONH) astrocytes and lamina cribrosa (LC) cells. TGF-β2 induces phosphorylation of canonical signaling proteins Smad2/3 but does not alter phosphorylation of non-canonical signaling proteins ERK1/2, p38, and JNK1/2 proteins in ONH astrocytes and LC cells. |
生物活性 | 1.The ED50 is <0.2 ng/mL as measured by mouse HT-2 cells. |
种属 | Human |
表达系统 | HEK293 |
标签 | Tag Free |
蛋白编号 | P61812 (A303-S414) |
基因 ID | |
中文名 | 重组人转化生长因子-β2 |
同用名 | TGF-beta-2; Cetermin; G-TSF; TGFB2; Polyergin; rHuTGF-β2 |
氨基酸序列 | ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS |
分子量 | Approximately 12.7 kDa |
纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
性状 | Lyophilized powder |
组分 | Lyophilized after extensive dialysis against 4 mM HCl. |
内毒素含量 | <1 EU/μg, determined by LAL method. |
复溶方法 | It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose). |
保存条件 & 期限 | Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. |
运输条件 | Room temperature in continental US; may vary elsewhere. |
相关文档
化学品安全说明书(MSDS)
下载MSDS质检证书(COA)
相关产品
-
CAS号:22227-26-5
3,5-双(三氟甲基)苯甲酰胺
¥110.00
-
CAS号:22227-26-5
3,5-双(三氟甲基)苯甲酰...
¥350.00
-
CAS号:146897-68-9
乳铁蛋白
¥850.00
-
CAS号:27200-12-0
二氢杨梅素
¥350.00
-
CAS号:27200-12-0
二氢杨梅素
¥230.00
-
CAS号:84-76-4
邻苯二甲酸二壬酯
¥450.00
-
CAS号:144284-76-4
2,4,7-三甲基茚
¥3,166.00
-
CAS号:484-76-4
奥卡宁
¥1,700.00
-
CAS号:704884-76-4
4,5-二氟-2-甲基苯酚
¥186.00
-
CAS号:84-76-4
邻苯二甲酸二壬酯
¥280.00
-
CAS号:84-76-4
邻苯二甲酸二壬酯
¥55.00
-
CAS号:84-76-4
邻苯二甲酸二壬酯
¥350.00