TNFRII 蛋白, Human (HEK293, hFc)|种属:Human|重组蛋白,TNFRII 蛋白, Human (HEK293, hFc)
产品编号:西域-HYP72025| MDL NO:Human
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描述 | TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (HEK293, hFc) is expressed by HEK293 and has a transmembrane region (L23-D257) with hFc tag at the C-terminus. |
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研究背景 | TNFRII (TNFRSF1B) protein is a single-pass type I membrane protein belonging to the tumor necrosis factor (TNF) family. TNFRII is the major signaling receptor for TNF-α. TNFRII protein is highly regulated and typically found in immune system cells. |
生物活性 | Measured by its binding ability in a functional ELISA. Immobilized TNF-α at 5 μg/mL can bind human TNFR2, the EC50 of human TNFR2 protein is 3.160-8.363 ng/mL. |
种属 | Human |
表达系统 | HEK293 |
标签 | C-hFc |
蛋白编号 | P20333 (L23-D257) |
基因 ID | |
中文名 | TNFRII 蛋白, Human (HEK293, hFc) |
同用名 | Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; TBP-2; TBPII; |
氨基酸序列 | LPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGD |
分子量 | Approximately 68 kDa |
纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
性状 | Lyophilized powder. |
组分 | Lyophilized from a 0.2 μm solution of Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
内毒素含量 | <1 EU/μg, determined by LAL method. |
复溶方法 | It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. |
保存条件 & 期限 | Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. |
运输条件 | Room temperature in continental US;may vary elsewhere. |
文件资料 | |
参考文献 |
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