MMAD-d8 Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8|西域试剂

MMAD-d₈ Demethyldolastatin 10-d₈; Monomethylauristatin D-d₈; Monomethyl Dolastatin 10-d₈,98.95%

产品编号：Bellancom-15581S| 分子式：C₄₁H₅₈D₈N₆O₆S| 分子量：779.11

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货号	价格	库存与货期
Bellancom-15581S	￥11000.00	杭州北京（现货）
Bellancom-15581S	￥25000.00	杭州北京（现货）
Bellancom-15581S	￥47000.00	杭州北京（现货）

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MMAD-d₈ Demethyldolastatin 10-d₈; Monomethylauristatin D-d₈; Monomethyl Dolastatin 10-d₈

产品介绍

MMAD-d₈D是MMAD的氘代形式。

生物活性

MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

体外研究

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (128.35 mM)

* "≥" means soluble, but saturation unknown.

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