Mps1-IN-3 hydrochloride|西域试剂

Mps1-IN-3 hydrochloride,98.06%

产品编号：Bellancom-12401A| 分子式：C₂₆H₃₂ClN₇O₄S| 分子量：574.09

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货号	价格	库存与货期
Bellancom-12401A	￥4200.00	杭州北京（现货）
Bellancom-12401A	￥6000.00	杭州北京（现货）
Bellancom-12401A	￥11000.00	杭州北京（现货）

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Mps1-IN-3 hydrochloride

产品介绍

Mps1-IN-3 hydrochloride 是一种有效且具有选择性的 Mps1 抑制剂，IC₅₀ 为 50 nM。Mps1-IN-3 hydrochloride 可抑制胶质母细胞瘤细胞的增殖，并在原位异种移植瘤模型中能有效地使胶质母细胞瘤对长春新碱敏感。

生物活性

Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC₅₀ value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model.

体外研究

Mps1-IN-3 hydrochloride (0.3-10 μM) inhibits the marker of mitotic cells cyclin B in a dose-dependent manner.
Mps1-IN-3 hydrochloride (2 μM) causes a dose-dependent escape from a checkpoint-mediated mitotic arrest.
Mps1-IN-3 hydrochloride (1-15 μM) inhibits the proliferation of U251 glioblastoma cells with an IC₅₀ value of ~5 µM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Mps1-IN-3 hydrochloride (2 mg/kg; IV, twice a week, for 3 weeks) effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft models.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Mps1-IN-3 hydrochloride (2 mg/kg; IV, twice a week, for 3 weeks) effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft models.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 20 mg/mL (34.84 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7419 mL	8.7094 mL	17.4189 mL
5 mM	0.3484 mL	1.7419 mL	3.4838 mL
10 mM	0.1742 mL	0.8709 mL	1.7419 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献