Allo-aca|西域试剂

Allo-aca,99.56%

产品编号：Bellancom-P3212| 分子式：C₄₈H₇₅N₁₃O₁₅| 分子量：1074.19

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-P3212		￥4500.00	杭州北京（现货）
Bellancom-P3212		￥12500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Allo-aca

产品介绍

Allo-aca 是一种瘦素肽模拟物，是一种有效的、特异性的瘦素受体 (leptin receptor) 拮抗剂肽。Allo-aca 在多种体外和体内模型中阻断瘦素信号传导和作用。

生物活性

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

体外研究

Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC₅₀ of 200 pM.
Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca inhibits VEGF mitogenic effects. Allo-aca inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (46.55 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9309 mL	4.6547 mL	9.3093 mL
5 mM	0.1862 mL	0.9309 mL	1.8619 mL
10 mM	0.0931 mL	0.4655 mL	0.9309 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture