Dxd-d<sub>5</sub> Exatecan-d<sub>5</sub> derivative for ADC|西域试剂

Dxd-d₅ Exatecan-d₅ derivative for ADC,98.63%

产品编号：Bellancom-13631DS| 分子式：C₂₆H₁₉D₅FN₃O₆| 分子量：498.51

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货号	包装	价格	库存与货期	购买量	操作

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Dxd-d₅ Exatecan-d₅ derivative for ADC

产品介绍

Dxd-d₅ 是 Dxd 的氘代物。Dxd 是一种有效的 DNA topoisomerase I 抑制剂，IC₅₀ 值为 0.31 μM，可用作靶作用于 HER2 的抗体偶联药物 ADC (DS-8201a) 的有效载荷。

生物活性

Dxd-d₅ is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) .

体外研究

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (200.60 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0060 mL	10.0299 mL	20.0598 mL
5 mM	0.4012 mL	2.0060 mL	4.0120 mL
10 mM	0.2006 mL	1.0030 mL	2.0060 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献