AKT Kinase Inhibitor hydrochloride|西域试剂

AKT Kinase Inhibitor hydrochloride,99.88%

产品编号：Bellancom-10249D| 分子式：C₁₆H₂₀ClN₇O₃| 分子量：393.83

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货号	价格	库存与货期
Bellancom-10249D	￥3500.00	杭州北京（现货）
Bellancom-10249D	￥6000.00	杭州北京（现货）
Bellancom-10249D	￥12600.00	杭州北京（现货）

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AKT Kinase Inhibitor hydrochloride

产品介绍

AKT Kinase Inhibitor hydrochloride 是一种具有抗肿瘤活性的 Akt 抑制剂。

生物活性

AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity.

体外研究

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (126.96 mM; ultrasonic and warming and heat to 60°C)

DMSO : 3.33 mg/mL (8.46 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5392 mL	12.6958 mL	25.3917 mL
5 mM	0.5078 mL	2.5392 mL	5.0783 mL
10 mM	0.2539 mL	1.2696 mL	2.5392 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献