Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide TFA)|西域试剂

Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide TFA)

产品编号：Bellancom-P1565A| 分子式：C₄₂H₆₅F₃N₁₄O₁₈S₂| 分子量：1175.17

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货号	价格	库存与货期
Bellancom-P1565A	￥800.00	杭州北京（现货）
Bellancom-P1565A	￥1800.00	杭州北京（现货）
Bellancom-P1565A	￥2800.00	杭州北京（现货）

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Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide TFA)

产品介绍

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) 是由 11 个氨基酸组成的多肽，可以与 Na⁺/K⁺-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide Disulfide TFA 能够增强一些大分子在皮肤中的传递。

生物活性

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules.

体外研究

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (85.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8509 mL	4.2547 mL	8.5094 mL
5 mM	0.1702 mL	0.8509 mL	1.7019 mL
10 mM	0.0851 mL	0.4255 mL	0.8509 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶