L-690330 hydrate|西域试剂

L-690330 hydrate

产品编号：Bellancom-101075A| 分子式：C₈H₁₄O₉P₂| 分子量：316.14

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-101075A		￥3000.00	杭州北京（现货）

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L-690330 hydrate

产品介绍

L-690330 hydrate是一种竞争性的肌醇单磷酸酶 (inositol monophosphatase (IMPase)) 抑制剂，对重组人和牛 IMPase 的 K_i 值为 0.27 μM 和 0.19 μM，对人和牛前脑皮层 IMPase 的为 K_i 值为 0.30 μM 和 0.42 μM。L-690330 hydrate对其敏感性是大鼠和小鼠的 IMPase 的 10 倍。

生物活性

L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with K_is of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate exhibits 10-fold more sensitive than mouse and rat IMPase.

体外研究

L-690330 hydrate (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

L-690330 hydrate (intracerebroventricular injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old male ICR mice
Dosage:	0.1 μmol
Administration:	Intracerebroventricular injection
Result:	Did not effect mice well-being by i.c.v injection.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old male ICR mice
Dosage:	0.1 μmol
Administration:	Intracerebroventricular injection
Result:	Did not effect mice well-being by i.c.v injection.

性状

Solid

溶解性数据

In Vitro:

H₂O : 31 mg/mL (98.06 mM; Need ultrasonic and warming)

DMSO : 31 mg/mL (98.06 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1632 mL	15.8158 mL	31.6316 mL
5 mM	0.6326 mL	3.1632 mL	6.3263 mL
10 mM	0.3163 mL	1.5816 mL	3.1632 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式