UNC7467|西域试剂

UNC7467,98.07%

产品编号：Bellancom-150607| 分子式：C₂₀H₁₃NO₃| 分子量：315.32

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-150607	￥1500.00	杭州北京（现货）
Bellancom-150607	￥2500.00	杭州北京（现货）
Bellancom-150607	￥5500.00	杭州北京（现货）
Bellancom-150607	￥9000.00	杭州北京（现货）
Bellancom-150607	￥14500.00	杭州北京（现货）

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UNC7467

产品介绍

UNC7467 是一种有效的 IP6K抑制剂，IP6K2、IP6K1 和 IP6K6 的 IC₅₀ 值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平。UNC7467 可用于肥胖研究。

生物活性

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.

体外研究

UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP₇ levels by 81% and 5-InsP₈ levels by 63%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis.
UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUC_last (6054 h•ng/mL for intra venous (i.v.) and 2527 h•ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Diet-induced obesity (DIO) mice
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; daily, for 4 weeks
Result:	Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.

Animal Model:

Diet-induced obesity (DIO) mice

Dosage:

5 mg/kg (Pharmacokinetic Analysis)

Administration:

Intravenous injection and intraperitoneal injection

Result:

1.19

route	iv	ip
Dose (mg/kg)	5	5
AUC_last (h*ng/mL)	6054	2527
CL (mL/min/kg)	13.7

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Diet-induced obesity (DIO) mice
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; daily, for 4 weeks
Result:	Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.

Animal Model:

Diet-induced obesity (DIO) mice

Dosage:

5 mg/kg (Pharmacokinetic Analysis)

Administration:

Intravenous injection and intraperitoneal injection

Result:

1.19

route	iv	ip
Dose (mg/kg)	5	5
AUC_last (h*ng/mL)	6054	2527
CL (mL/min/kg)	13.7

性状

Solid

溶解性数据

In Vitro:

DMSO : 14.29 mg/mL (45.32 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1714 mL	15.8569 mL	31.7138 mL
5 mM	0.6343 mL	3.1714 mL	6.3428 mL
10 mM	0.3171 mL	1.5857 mL	3.1714 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式