RAGE antagonist peptide TFA|西域试剂

RAGE antagonist peptide TFA,99.71%

产品编号：Bellancom-P2268A| 分子式：C₅₉H₁₀₂F₃N₁₃O₁₉S| 分子量：1386.58

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P2268A		￥890.00	杭州北京（现货）
Bellancom-P2268A		￥2700.00	杭州北京（现货）

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RAGE antagonist peptide TFA

产品介绍

RAGE antagonist peptide TFA 是一种晚期糖基化终产物 (RAGE) 拮抗剂。RAGE antagonist peptide TFA 可阻断 RAGE 和几个重要配体 HMGB-1，S100P，S100A4 的结合。RAGE antagonist peptide TFA 具有抗肿瘤和抗炎活性。

生物活性

RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities.

体外研究

RAGE antagonist peptide TFA (RAP) reduces the ability of the ligands to stimulate RAGE activation of NFκB in cancer cells in vitro.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

RAGE antagonist peptide TFA (RAP, 100 µg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo.
RAGE antagonist peptide TFA (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth.
In mice bearing asthma, RAGE antagonist peptide TFA (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide TFA also reduces total, cytoplasmic and nuclear levels of β-catenin, enhances β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice.
Dosage:	100 µg
Administration:	Intratumoral delivery (or intraperitoneally).
Result:	Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice.
Dosage:	100 µg
Administration:	Intratumoral delivery (or intraperitoneally).
Result:	Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection.

性状

Solid

溶解性数据

In Vitro:

H₂O : 25 mg/mL (18.03 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.7212 mL	3.6060 mL	7.2120 mL
5 mM	0.1442 mL	0.7212 mL	1.4424 mL
10 mM	0.0721 mL	0.3606 mL	0.7212 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture