Kisspeptin-10, human TFA 亲吻促动素-10三氟乙酸盐(人源)|西域试剂

Kisspeptin-10, human TFA 亲吻促动素-10三氟乙酸盐(人源),98.10%

产品编号：Bellancom-P0254A| 分子式：C₆₃H₈₃N₁₇O₁₄.C₂HF₃O₂| 分子量：1416.46

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P0254A		￥1200.00	杭州北京（现货）
Bellancom-P0254A		￥4100.00	杭州北京（现货）

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Kisspeptin-10, human TFA 亲吻促动素-10三氟乙酸盐(人源)

产品介绍

Kisspeptin-10, human TFA 是一种有效的血管收缩剂和血管生成抑制剂。Kisspeptin-10, human TFA 通过其受体 GPR54 来抑制肿瘤转移作用。Kisspeptin-10-GPR54 系统在胚胎肾脏发育中起重要作用。Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达来诱导成骨细胞分化。

生物活性

Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.

体外研究

Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes^[4]. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (70.60 mM; Need ultrasonic)

H₂O : 4 mg/mL (2.82 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.7060 mL	3.5299 mL	7.0599 mL
5 mM	0.1412 mL	0.7060 mL	1.4120 mL
10 mM	0.0706 mL	0.3530 mL	0.7060 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture