Orexin A (human, rat, mouse) (TFA) Hypocretin-1 (human, rat, mouse (TFA))|西域试剂

Orexin A (human, rat, mouse) (TFA) Hypocretin-1 (human, rat, mouse (TFA)),98.33%

产品编号：Bellancom-106224A| 分子式：C₁₅₄H₂₄₄N₄₇F₃O₄₆S₄| 分子量：3675.12

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-106224A		￥4400.00	杭州北京（现货）
Bellancom-106224A		￥18000.00	杭州北京（现货）

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Orexin A (human, rat, mouse) (TFA) Hypocretin-1 (human, rat, mouse (TFA))

产品介绍

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA 是一种 33 氨基酸兴奋性神经肽，参与多种中枢和外周过程。Orexin A (human, rat, mouse) TFA 是一种特异性、高亲和力的 G 蛋白偶联受体 OX1R 激动剂，在调节摄食行为中起重要作用。Orexin A (human, rat, mouse) TFA 是一种有效的抗伤害和抗痛觉过敏的活性分子。

生物活性

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

体外研究

Orexin A (human, rat, mouse) TFA has high affinity for OX1R, with 38 nM IC₅₀ and 34 nM EC₅₀ values in the the [Ca^2﹢]i transient assay.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Orexin A (human, rat, mouse) TFA (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively.
Orexin A (human, rat, mouse) TFA (3, 10 and 30 mg/kg; i.v.) is given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female mice (mouse carrageenan-induced thermal hyperalgesia test
Dosage:	3, 10 and 30 mg/kg
Administration:	i.v.; 5 min pre-test
Result:	Significantly increased the latency to response at 10 and 30 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female mice (mouse carrageenan-induced thermal hyperalgesia test
Dosage:	3, 10 and 30 mg/kg
Administration:	i.v.; 5 min pre-test
Result:	Significantly increased the latency to response at 10 and 30 mg/kg.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (27.21 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2721 mL	1.3605 mL	2.7210 mL
5 mM	0.0544 mL	0.2721 mL	0.5442 mL
10 mM	0.0272 mL	0.1360 mL	0.2721 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture