CTAP TFA|西域试剂

CTAP TFA,99.56%

产品编号：Bellancom-P1335A| 分子式：C₅₃H₇₀F₃N₁₃O₁₂S₂| 分子量：1218.32

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P1335A	￥2200.00	杭州北京（现货）
Bellancom-P1335A	￥5500.00	杭州北京（现货）
Bellancom-P1335A	￥9300.00	杭州北京（现货）

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CTAP TFA

产品介绍

CTAP TFA 是一种强效、高选择性的、可透过血脑屏障的阿片受体 (μ opioid receptor) 拮抗剂，IC₅₀ 为 3.5 nM。CTAP TFA 对 δ opioid 受体 (IC₅₀=4500 nM) 和生长抑素受体 (somatostatin receptors) 具有超过 1200 倍的选择性。CTAP TFA 可用于L -多巴胺 (HY-N0304) 诱导的运动障碍 (LID) 和阿片类活性分子过量或成瘾的研究。

生物活性

CTAP TFA is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC₅₀ of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC₅₀=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction.

体外研究

体内研究

CTAP TFA (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect.
CTAP TFA (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements.
CTAP TFA is stable in the blood and serum of rats (T_1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance.
CTAP TFA is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats
Dosage:	0, 0.1, 0.5, 1 mg/kg
Administration:	IP, single
Result:	Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats
Dosage:	0, 0.1, 0.5, 1 mg/kg
Administration:	IP, single
Result:	Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (82.08 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8208 mL	4.1040 mL	8.2080 mL
5 mM	0.1642 mL	0.8208 mL	1.6416 mL
10 mM	0.0821 mL	0.4104 mL	0.8208 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen