Abemaciclib metabolite M18 hydrochloride LSN3106729 hydrochloride|西域试剂

Abemaciclib metabolite M18 hydrochloride LSN3106729 hydrochloride,98.01%

产品编号：Bellancom-126534A| 分子式：C₂₅H₂₉ClF₂N₈O| 分子量：531.00

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货号	价格	库存与货期
Bellancom-126534A	￥3500.00	杭州北京（现货）
Bellancom-126534A	￥5500.00	杭州北京（现货）
Bellancom-126534A	￥9900.00	杭州北京（现货）
Bellancom-126534A	￥16500.00	杭州北京（现货）
Bellancom-126534A	￥22500.00	杭州北京（现货）

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Abemaciclib metabolite M18 hydrochloride LSN3106729 hydrochloride

产品介绍

Abemaciclib metabolite M18 (LSN3106729) hydrochloride，Abemaciclib (HY-16297A) 的代谢物，是一种具有抗肿瘤活性的 CDK 抑制剂。Abemaciclib metabolite M18 hydrochloride 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。

生物活性

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader.

体外研究

Abemaciclib metabolite M18 hydrochloride exhibits T_1/2 of 43.1 hr in plasma in healthy subjects.
CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, CDK4/6 inhibitors alter cancer cell biology in other ways^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8⁺ T cells^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8⁺ T cells^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (235.40 mM; Need ultrasonic)

H₂O : 100 mg/mL (188.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8832 mL	9.4162 mL	18.8324 mL
5 mM	0.3766 mL	1.8832 mL	3.7665 mL
10 mM	0.1883 mL	0.9416 mL	1.8832 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶