HS014 TFA
| 产品介绍 | HS014 TFA 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM。HS014 TFA 增加自由喂养大鼠的食物摄取量。 | ||||||
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| 生物活性 | HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats. | ||||||
| 体外研究 | |||||||
| 体内研究 |
Pretreatment with HS014 TFA blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||
| 体内研究 |
Pretreatment with HS014 TFA blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||
| 性状 | Solid | ||||||
| 溶解性数据 | |||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||
| 储存方式 |
Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||
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