Antisauvagine-30 TFA aSvg-30 TFA|西域试剂

Antisauvagine-30 TFA aSvg-30 TFA,98.01%

产品编号：Bellancom-P1107A| 分子式：C₁₆₃H₂₇₅N₄₈F₃O₄₉S| 分子量：3764.28

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P1107A		￥3200.00	杭州北京（现货）
Bellancom-P1107A		￥5500.00	杭州北京（现货）

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Antisauvagine-30 TFA aSvg-30 TFA

产品介绍

Antisauvagine-30 TFA (aSvg-30 TFA) 是有效的、高度选择性的、竞争性的 CRF₂ 受体 的多肽拮抗剂。Antisauvagine-30 TFA对 mCRFR2β 和 CRFR1 的 K_d 值分别为1.4 nM 和150 nM。

生物活性

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF₂ receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a K_d of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively^[4].

体外研究

Antisauvagine-30 (aSvg-30) prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. Antisauvagine-30 (aSvg-30) did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Antisauvagine-30 (aSvg-30; i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice.
Antisauvagine-30 (aSvg-30) injected i.c.v. elicits a significant anxiogenic effect.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nine-week-old male BALB/c mice.
Dosage:	400 ng/0.5 μl per mouse.
Administration:	Administered bilaterally by a microinjector (intrahippocampal (i.h.) injection).
Result:	Prevented the stress-induced enhancement of fear conditioning.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nine-week-old male BALB/c mice.
Dosage:	400 ng/0.5 μl per mouse.
Administration:	Administered bilaterally by a microinjector (intrahippocampal (i.h.) injection).
Result:	Prevented the stress-induced enhancement of fear conditioning.

性状

Solid

溶解性数据

In Vitro:

H₂O : 25 mg/mL (6.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2657 mL	1.3283 mL	2.6566 mL
5 mM	0.0531 mL	0.2657 mL	0.5313 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture