Orexin B, human TFA Human orexin B TFA|西域试剂

Orexin B, human TFA Human orexin B TFA,98.08%

产品编号：Bellancom-P1339A| 分子式：C₁₂₃H₂₁₂N₄₄O₃₅S.C₂HF₃O₂| 分子量：3013.36

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P1339A	￥2200.00	杭州北京（现货）
Bellancom-P1339A	￥3400.00	杭州北京（现货）
Bellancom-P1339A	￥13000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Orexin B, human TFA Human orexin B TFA

产品介绍

Orexin B, human (TFA) 是 Orexin 受体的内源性激动剂，与OX1和OX2结合的 K_i 值分别为 420 和 36 nM。

生物活性

Orexin B, human (TFA) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

体外研究

Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor.
Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC₅₀ of 36 nM in the binding assay and an EC₅₀ of 60 nM in the [Ca²⁺]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC₅₀ in the competitive binding assay and the EC₅₀ in the [Ca²⁺]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-200 g).
Dosage:	3 nM and 30 nM.
Administration:	Administered in a 5 mL bolus through a catheter placed in the left lateral ventricle in early light phase.
Result:	Significantly augmented food intake.

体内研究

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-200 g).
Dosage:	3 nM and 30 nM.
Administration:	Administered in a 5 mL bolus through a catheter placed in the left lateral ventricle in early light phase.
Result:	Significantly augmented food intake.