AC-VEID-CHO TFA|西域试剂

AC-VEID-CHO TFA,98.0%

产品编号：Bellancom-108312A| 分子式：C₂₄H₃₇F₃N₄O₁₁| 分子量：614.57

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-108312A		￥2970.00	杭州北京（现货）

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AC-VEID-CHO TFA

产品介绍

AC-VEID-CHO (TFA) 是一种多肽来源的半胱天冬酶抑制剂，对 Caspase-6、Caspase-3 和 Caspase-7 具有抑制作用，IC₅₀ 值分别为 16.2 nM、13.6 nM 和162.1 nM。AC-VEID-CHO (TFA) 可被用于阿尔茨海默病、亨廷顿病等神经退行性疾病的研究。

生物活性

AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease.

体外研究

AC-VEID-CHO (TFA) has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively.
Ac-VEID-CHO is predominantly excluded from accessing the intracellular environment (0.16% cellular accumulation) and lacks any activity with an IC₅₀ value of ＞100 μM in the cellular assay.
AC-VEID-CHO (TFA) (also inactive in lamin degradation assay) is clearly able to inhibit VEIDase activity with an IC₅₀ value of 0.49 μM when the membrane barrier is removed.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 1 mg/mL (1.63 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6272 mL	8.1358 mL	16.2715 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture