(S)-UFR2709 hydrochloride|西域试剂

(S)-UFR2709 hydrochloride,98.08%

产品编号：Bellancom-137231B| 分子式：C₁₃H₁₈ClNO₂| 分子量：255.74

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-137231B	￥1000.00	杭州北京（现货）
Bellancom-137231B	￥1500.00	杭州北京（现货）
Bellancom-137231B	￥3000.00	杭州北京（现货）
Bellancom-137231B	￥4500.00	杭州北京（现货）
Bellancom-137231B	￥7000.00	杭州北京（现货）

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(S)-UFR2709 hydrochloride

产品介绍

(S)-UFR2709 (hydrochloride) 是一种竞争性的 nAChR 拮抗剂，并显示出较强的亲和力，对 α₄β₂ nAChR 的亲和力比对 α₇ nAChR 的高。(S)-UFR2709 (hydrochloride) 在偏好酒精的老鼠中减少焦虑，并且可以减少其酒精摄入和对酒精偏好。(S)-UFR2709 (hydrochloride) 是抗焦虑试剂，可用于研究尼古丁成瘾。

生物活性

(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α₄β₂ nAChRs than for α₇ nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction.

体外研究

Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, which is a molecular target for the treatment of alcohol abuse and dependence.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

(S)-UFR2709 (hydrochloride) (50-100 μg/ml; 3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test, and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s, respectively at 50 and 100 μg/ml.
(S)-UFR2709 (hydrochloride) (50-100 μg/ml) decreases nicotine-evoked mRNA expression of α4 nACh receptor subunit, but UFR2709 has less effect on α4 nACh receptor subunit in the brain of adult zebrafish.
(S)-UFR2709 (hydrochloride) (intraperitoneal injection; 1-10 mg/kg; daily; 17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 is 2.5 mg/kg, it induces a 56% reduction in alcohol consumption. (S)-UFR2709 (hydrochloride) does not affect the weight or locomotor activity of the rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-alcohol-drinking UChB rats
Dosage:	10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg
Administration:	Intraperitoneal injection; 1-10 mg/kg; daily; 17 days
Result:	Did not affect the weight or locomotor activity and reduced ethanol consumption and preference.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-alcohol-drinking UChB rats
Dosage:	10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg
Administration:	Intraperitoneal injection; 1-10 mg/kg; daily; 17 days
Result:	Did not affect the weight or locomotor activity and reduced ethanol consumption and preference.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (391.02 mM; Need ultrasonic)

DMSO : 50 mg/mL (195.51 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9102 mL	19.5511 mL	39.1022 mL
5 mM	0.7820 mL	3.9102 mL	7.8204 mL
10 mM	0.3910 mL	1.9551 mL	3.9102 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (195.51 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.78 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.78 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.78 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.78 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.78 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.78 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。