Disitertide diammonium P144 diammonium|西域试剂

Disitertide diammonium P144 diammonium,98.01%

产品编号：Bellancom-P0118B| 分子式：C₆₈H₁₁₅N₁₉O₂₂S₂| 分子量：1614.88

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P0118B	￥950.00	杭州北京（现货）
Bellancom-P0118B	￥2900.00	杭州北京（现货）
Bellancom-P0118B	￥5050.00	杭州北京（现货）

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Disitertide diammonium P144 diammonium

产品介绍

Disitertide (P144) diammonium 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide diammonium 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。

生物活性

Disitertide (P144) diammonium is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide diammonium is also a PI3K inhibitor and an apoptosis inducer^[4]^[5].

体外研究

Disitertide (P144, 100 μg/mL) diammonium suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) diammonium abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (10 μg/mL to 200 μg/mL) diammonium affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Mouse embryo osteoblast precursor MC3T3-E1 cells.
Concentration:	100 μg/mL
Incubation Time:	4 h
Result:	Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.

体内研究
(In Vivo)

Disitertide (P144, Topical application, 300 μg/mL) diammonium may promote scar maturation and improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Human hypertrophic scars were implanted in 60 nude mice^[4].
Dosage:	300 μg/mL was added the Lipogel.
Administration:	Topical application daily administered.
Result:	Successful shedding was achieved in 83.3% of the xenografts.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Human hypertrophic scars were implanted in 60 nude mice^[4].
Dosage:	300 μg/mL was added the Lipogel.
Administration:	Topical application daily administered.
Result:	Successful shedding was achieved in 83.3% of the xenografts.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Human hypertrophic scars were implanted in 60 nude mice^[4].
Dosage:	300 μg/mL was added the Lipogel.
Administration:	Topical application daily administered.
Result:	Successful shedding was achieved in 83.3% of the xenografts.

性状

Solid

溶解性数据

In Vitro:

DMSO : 10 mg/mL (6.19 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.6192 mL	3.0962 mL	6.1924 mL
5 mM	0.1238 mL	0.6192 mL	1.2385 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶