Orexin B, rat, mouse TFA Rat orexin B TFA; Orexin B (mouse (TFA))|西域试剂

Orexin B, rat, mouse TFA Rat orexin B TFA; Orexin B (mouse (TFA)),98.49%

产品编号：Bellancom-P1349A| 分子式：C₁₂₈H₂₁₆F₃N₄₅O₃₆S| 分子量：3050.42

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P1349A		￥3000.00	杭州北京（现货）
Bellancom-P1349A		￥7500.00	杭州北京（现货）

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Orexin B, rat, mouse TFA Rat orexin B TFA; Orexin B (mouse (TFA))

产品介绍

Orexin B, rat, mouse (Rat orexin B) TFA 是一种内源性增食欲素受体 (Orexin receptor) 激动剂。Orexin B, rat, mouse TFA 结合并激活两个密切相关的孤儿 G 蛋白偶联受体 OX1-R 和 OX2-R。Orexin B, rat, mouse TFA 刺激食物摄入和能量消耗，并在睡眠-觉醒调节中发挥重要作用。

生物活性

Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.

体外研究

OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC₅₀ of 36 nM in the binding assay and an EC₅₀ of 60 nM in the [Ca²⁺]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC₅₀ in the competitive binding assay and the EC₅₀ in the [Ca²⁺]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (32.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.3278 mL	1.6391 mL	3.2782 mL
5 mM	0.0656 mL	0.3278 mL	0.6556 mL
10 mM	0.0328 mL	0.1639 mL	0.3278 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture