AZD 2066 hydrate|西域试剂

AZD 2066 hydrate

产品编号：Bellancom-110255A| 分子式：C₁₉H₁₆ClN₅O₂.1/4H₂O| 分子量：386.33

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-110255A		￥5850.00	杭州北京（现货）

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AZD 2066 hydrate

产品介绍

AZD 2066 hydrate 是一种选择性的，具有口服活性和可透过血脑屏障的 mGluR5 的拮抗剂。AZD 2066 hydrate 具有抗伤害作用。

生物活性

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects.

体外研究

AZD 2066 (1-10 μM) inhibits Ca²⁺ response, with IC₅₀s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively.
AZD 2066 (1-10 μM) inhibits the oscillatory Ca²⁺ response which induced by bath application of DHPG, and blocks either DHPG or Quis eﬀects in mGlu5/HEK cells.
AZD 2066 (1-10 μM) has less eﬀective in striatal neurons.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

AZD 2066 (0.03-30 mg/kg; p.o.) shows discriminative effects in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (weighing 240-250 g)
Dosage:	0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:	P.o. (60 minutes after administration)
Result:	Caused full and dose-dependent AZD9272-appropriate responding.

体内研究

AZD 2066 (0.03-30 mg/kg; p.o.) shows discriminative effects in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (weighing 240-250 g)
Dosage:	0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:	P.o. (60 minutes after administration)
Result:	Caused full and dose-dependent AZD9272-appropriate responding.