LP-922761 hydrate
| 产品介绍 | LP-922761 hydrate 是一种有效的，选择性的，具有口服活性的 AAK1 抑制剂，在酶和细胞分析中 IC50 分别为 4.8 nM 和 7.6 nM。LP-922761 hydrate 还抑制 BMP-2 诱导蛋白激酶 (BIKE)，IC50 为 24 nM。LP-922761 hydrate 对细胞 GAK，阿片类活性分子，肾上腺素 α2 或 GABAa 受体无明显活性。 | |||||||||
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| 生物活性 | LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors. | |||||||||
| 体外研究 | ||||||||||
| 体内研究 |
In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 体内研究 |
In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 性状 | Solid | |||||||||
| 溶解性数据 | ||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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| 参考文献 |
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