JMV 449 acetate|西域试剂

JMV 449 acetate,99.91%

产品编号：Bellancom-P1256C| 分子式：C₄₀H₇₀N₈O₉| 分子量：807.03

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P1256C		￥7000.00	杭州北京（现货）

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JMV 449 acetate

产品介绍

JMV 449 acetate 是一种有效的神经降压素受体 (neurotensin receptor) 激动剂。JMV 449 acetate 显示抑制 ¹²⁵I-neurotensin 与新生小鼠脑结合的 IC₅₀ 为 0.15 nM，对收缩豚鼠回肠的 EC₅₀ 为 1.9 nM。JMV 449 acetate 对小鼠具有高效、持久的降温和缓解疼痛作用。

生物活性

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.

体外研究

体内研究

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss albino mice
Dosage:	120 pmol/mouse
Administration:	I.c.v.
Result:	Showed dose-response relation-ships for the analgesic effect.

体内研究

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss albino mice
Dosage:	120 pmol/mouse
Administration:	I.c.v.
Result:	Showed dose-response relation-ships for the analgesic effect.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (123.91 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2391 mL	6.1956 mL	12.3911 mL
5 mM	0.2478 mL	1.2391 mL	2.4782 mL
10 mM	0.1239 mL	0.6196 mL	1.2391 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture