Norleual TFA
| 产品介绍 | Norleual TFA 是一种血管紧张素 (Ang) IV 类似物，是一种肝细胞生长因子 (HGF)/c-Met 抑制剂，IC50 为 3 pM。Norleual TFA 还是一种 AT4 拮抗剂，具有强大的抗血管生成活性。 | ||||||
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| 生物活性 | Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities. | ||||||
| 体外研究 |
Norleual TFA（20 和 50 pM）显着降低 HGF 依赖性 c-Met 和 Gab1 磷酸化。20 pM Norleual TFA 显着降低 HEK293 细胞中 HGF 启动的 Gab1 和 c-Met 之间的关联。Norleual TFA 显着减弱 HGF 依赖性 c-Met 激活和下游信号。Norleual TFA（1 pM-1 μM；4 天）能够在 MDCK 细胞中以皮摩尔范围内的浓度抑制多种细胞类型中的 HGF 依赖性信号转导、增殖、迁移和侵袭。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||
| 体内研究 |
Norleual TFA（50 μg/kg；腹腔注射；每天 1 次，持续 2 周；C57BL/6 小鼠）抑制 B16-F10 小鼠黑色素瘤细胞在肺部的定植。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||
| 体内研究 |
Norleual TFA（50 μg/kg；腹腔注射；每天 1 次，持续 2 周；C57BL/6 小鼠）抑制 B16-F10 小鼠黑色素瘤细胞在肺部的定植。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||
| 性状 | Solid | ||||||
| 溶解性数据 | |||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||
| 储存方式 |
Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) | ||||||
| 参考文献 |
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