AZ12601011|西域试剂

AZ12601011,99.88%

产品编号：Bellancom-122856| 分子式：C₁₉H₁₅N₅| 分子量：313.36

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-122856	￥3500.00	杭州北京（现货）
Bellancom-122856	￥5800.00	杭州北京（现货）
Bellancom-122856	￥15500.00	杭州北京（现货）
Bellancom-122856	￥21500.00	杭州北京（现货）

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AZ12601011

产品介绍

AZ12601011 是一种具有口服活性的，选择性 TGFBR1 激酶抑制剂，IC₅₀ 为 18 nM，K_d 为 2.9 nM。AZ12601011 通过选择性的抑制 ALK4，TGFBR1 和 ALK7 来抑制 SMAD2 的磷酸化。AZ12601011 抑制乳腺肿瘤的生长。

生物活性

AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC₅₀ of 18 nM and a K_d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth .

体外研究

AZ12601011 (0.01-10 μM; for 20 minutes) completely inhibits Phosphorylation of SMAD2 .
AZ12601011 (0.01 µM-10 µM) inhibits the activity of ALK4, ALK7 and TGFBR1 .
AZ12601011 inhibits 4T1 cells growth in vitro (IC₅₀=0.4µM) .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	NIH3T3, HaCaT, C2C12, T47D cells
Concentration:	0.01, 0.03, 0.1, 0.3, 1, 3, 10 μM
Incubation Time:	20 minutes
Result:	Completely inhibited Phosphorylation of SMAD2.

体内研究
(In Vivo)

AZ12601011 (50mg/kg; oral gavage; twice daily; for 25 days) inhibits tumour growth and metastasis in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice at greater than 18g with tumour
Dosage:	50mg/kg
Administration:	Oral gavage; twice daily; for 25 days
Result:	Inhibited tumour growth and metastasis in vivo.

体内研究

AZ12601011 (50mg/kg; oral gavage; twice daily; for 25 days) inhibits tumour growth and metastasis in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice at greater than 18g with tumour
Dosage:	50mg/kg
Administration:	Oral gavage; twice daily; for 25 days
Result:	Inhibited tumour growth and metastasis in vivo.

体内研究

AZ12601011 (50mg/kg; oral gavage; twice daily; for 25 days) inhibits tumour growth and metastasis in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice at greater than 18g with tumour
Dosage:	50mg/kg
Administration:	Oral gavage; twice daily; for 25 days
Result:	Inhibited tumour growth and metastasis in vivo.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (15.96 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1912 mL	15.9561 mL	31.9122 mL
5 mM	0.6382 mL	3.1912 mL	6.3824 mL
10 mM	0.3191 mL	1.5956 mL	3.1912 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式