Apelin-13 TFA|西域试剂

Apelin-13 TFA,98.0%

产品编号：Bellancom-P1944A| 分子式：C₇₁H₁₁₂F₃N₂₃O₁₈S| 分子量：1664.85

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P1944A	￥550.00	杭州北京（现货）
Bellancom-P1944A	￥1650.00	杭州北京（现货）
Bellancom-P1944A	￥2800.00	杭州北京（现货）

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Apelin-13 TFA

产品介绍

Apelin-13 TFA 是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体，激活G蛋白偶联受体的 EC₅₀ 值为 0.37 nM。Apelin-13 TFA 具有扩张血管和降压作用。Apelin-13 TFA 也可用于 2 型糖尿病及代谢综合征的研究。

生物活性

Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC₅₀ value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome.

体外研究

体内研究

Apelin-13 (200 µg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels.
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)
Dosage:	200 µg/kg
Administration:	IP, daily for 4 weeks
Result:	Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.

Animal Model:	Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)^[4]
Dosage:	10 and 100 μM
Administration:	ICV, single dosage
Result:	Increased the spontaneous discharges in the majority of pallidal neurons.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)
Dosage:	200 µg/kg
Administration:	IP, daily for 4 weeks
Result:	Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.

Animal Model:	Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)^[4]
Dosage:	10 and 100 μM
Administration:	ICV, single dosage
Result:	Increased the spontaneous discharges in the majority of pallidal neurons.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (30.03 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.6007 mL	3.0033 mL	6.0065 mL
5 mM	0.1201 mL	0.6007 mL	1.2013 mL
10 mM	0.0601 mL	0.3003 mL	0.6007 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶