Aldometanib LXY-05-029|西域试剂

Aldometanib LXY-05-029,99.73%

产品编号：Bellancom-148189| 分子式：C₂₇H₄₃Cl₂IN₂| 分子量：593.45

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-148189	￥900.00	杭州北京（现货）
Bellancom-148189	￥1440.00	杭州北京（现货）
Bellancom-148189	￥2750.00	杭州北京（现货）
Bellancom-148189	￥4350.00	杭州北京（现货）
Bellancom-148189	￥7000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Aldometanib LXY-05-029

产品介绍

Aldometanib (LXY-05-029) 是一种醛缩酶抑制剂。Aldometanib 可以激活溶酶体腺苷-磷酸活化蛋白激酶 AMPK 并降低血糖。Aldometanib 可用于代谢稳态的研究。

生物活性

Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.

体外研究

Aldometanib (0-1000 nM; 2 h) activates AMPK by preventing aldolase from binding to FBP to engender a pseudo-starvation signal.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Mouse primary hepatocytes, MEFs cells
Concentration:	0-1000 nM
Incubation Time:	2 h
Result:	Activated AMPK in mouse embryonic fibroblasts (MEFs) and mouse primary hepatocytes cells.

Immunofluorescence

Cell Line:	MEFs cells
Concentration:	5 nM
Incubation Time:	2 h
Result:	Inhibited TRPVs and induces AXIN lysosomal translocation.

体内研究
(In Vivo)

Aldometanib (oral; 0-10 mpk) reduces blood glucose in lean mice.
Aldometanib (oral; 2-10 mpk; twice daily; for a week) reduces blood glucose and alleviates fatty liver in obese hyperglycaemic mice.
Aldometanib alleviates fatty liver and nonalcoholic steatohepatitis.
Aldometanib (oral; 2mpk; twice-daily; for a month) alleviates liver fibrosis in NASH mice.
Aldometanib (oral; 0-50 μM; 0-50 days) extends lifespan in C. elegans via the lysosomal pathway.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Lean mice
Dosage:	0-10 mpk
Administration:	Oral
Result:	Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.

Animal Model:	Obese hyperglycaemic mice
Dosage:	2-10 mpk
Administration:	Oral, twice daily, for a week
Result:	Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.

Animal Model:	NASH mice
Dosage:	2 mpk
Administration:	Oral, twice-daily, for a month
Result:	Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.

Animal Model:	C. elegans
Dosage:	0-50 μM
Administration:	Oral, 0-50 days
Result:	Promoted oxidative stress resistance and mitochondrial functions in C. elegans.

Animal Model:	C57BL/6 mice
Dosage:	100 μg/mL
Administration:	Oral
Result:	Extended lifespan, elevated NAD^＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Lean mice
Dosage:	0-10 mpk
Administration:	Oral
Result:	Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.

Animal Model:	Obese hyperglycaemic mice
Dosage:	2-10 mpk
Administration:	Oral, twice daily, for a week
Result:	Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.

Animal Model:	NASH mice
Dosage:	2 mpk
Administration:	Oral, twice-daily, for a month
Result:	Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.

Animal Model:	C. elegans
Dosage:	0-50 μM
Administration:	Oral, 0-50 days
Result:	Promoted oxidative stress resistance and mitochondrial functions in C. elegans.

Animal Model:	C57BL/6 mice
Dosage:	100 μg/mL
Administration:	Oral
Result:	Extended lifespan, elevated NAD^＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Lean mice
Dosage:	0-10 mpk
Administration:	Oral
Result:	Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.

Animal Model:	Obese hyperglycaemic mice
Dosage:	2-10 mpk
Administration:	Oral, twice daily, for a week
Result:	Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.

Animal Model:	NASH mice
Dosage:	2 mpk
Administration:	Oral, twice-daily, for a month
Result:	Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.

Animal Model:	C. elegans
Dosage:	0-50 μM
Administration:	Oral, 0-50 days
Result:	Promoted oxidative stress resistance and mitochondrial functions in C. elegans.

Animal Model:	C57BL/6 mice
Dosage:	100 μg/mL
Administration:	Oral
Result:	Extended lifespan, elevated NAD^＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (168.51 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6851 mL	8.4253 mL	16.8506 mL
5 mM	0.3370 mL	1.6851 mL	3.3701 mL
10 mM	0.1685 mL	0.8425 mL	1.6851 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献