Semaglutide TFA 索马鲁肽三氟乙酸|西域试剂

Semaglutide TFA 索马鲁肽三氟乙酸,99.90%

产品编号：Bellancom-114118A| 分子式：C₁₈₉H₂₉₂F₃N₄₅O₆₁| 分子量：4227.66

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货号	价格	库存与货期
Bellancom-114118A	￥2600.00	杭州北京（现货）
Bellancom-114118A	￥5600.00	杭州北京（现货）
Bellancom-114118A	￥8000.00	杭州北京（现货）
Bellancom-114118A	￥16000.00	杭州北京（现货）

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Semaglutide TFA 索马鲁肽三氟乙酸

产品介绍

Semaglutide TFA 是人胰高血糖素样肽-1 的一个长效类似物，是人胰高血糖素样肽-1(GLP-1) 受体激动剂。Semaglutide TFA 有潜力用于 2 型糖尿病的研究。

生物活性

Semaglutide TFA, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide TFA has the potential for type 2 diabetes treatment.

体外研究

Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib⁸, Arg³⁴) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1^[3.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to liraglutide in most parameters. Semaglutide lowers blood glucose by stimulating the release of insulin and also lowers body weight.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (23.65 mM; ultrasonic and warming and heat to 60°C)

H₂O : 100 mg/mL (23.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2365 mL	1.1827 mL	2.3654 mL
5 mM	0.0473 mL	0.2365 mL	0.4731 mL
10 mM	0.0237 mL	0.1183 mL	0.2365 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture