Dalazatide TFA ShK-186 TFA|西域试剂

Dalazatide TFA ShK-186 TFA,98.44%

产品编号：Bellancom-P3507A| 分子式：C₁₈₆H₂₉₇F₃N₅₇PS₇| 分子量：4556.10

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P3507A		￥5000.00	杭州北京（现货）
Bellancom-P3507A		￥12500.00	杭州北京（现货）

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Dalazatide TFA ShK-186 TFA

产品介绍

Dalazatide (ShK-186) TFA 是一种特异性的 Kv1.3 钾通道肽抑制剂。Dalazatide TFA 可用于自身免疫性疾病，如如多发性硬化症 (MS)、红斑狼疮、银屑病、类风湿性关节炎、1 型糖尿病和炎症性肠病的研究。

生物活性

Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.

体外研究

Dalazatide (ShK-186) (0-1000 pM) TFA 以剂量依赖的方式阻断卵巢特异性 GFP+ 效应记忆 T (Tem) 细胞中的 Kv1.3 电流，K_d 为 65 ± 5 pM。
Dalazatide (0-100 nM; 3 days) TFA 以剂量依赖的方式抑制 CCR7⁻ T 细胞增殖。
Dalazatide (100 nM; 30 min) TFA 通过抑制钙信号通路固定炎症部位的效应记忆 T (Tem) 细胞，从而阻止 β1 整合素激活。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	CCR7⁻ T cell
Concentration:	0-100 nM
Incubation Time:	3 days
Result:	Inhibited cell proliferation with an IC₅₀ of 180 ± 37 pM.

体内研究
(In Vivo)

Dalazatide (ShK-186) (100 μg/kg; s.c.; once) TFA 在大鼠中抑制延迟型超敏反应，并抑制 Tem 细胞的体内运动和激活。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Lewis rats rats, delayed-type hypersensitivity (DTH) model
Dosage:	100 μg/kg
Administration:	Subcutaneous injection, once
Result:	Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.

体内研究

Dalazatide (ShK-186) (100 μg/kg; s.c.; once) TFA 在大鼠中抑制延迟型超敏反应，并抑制 Tem 细胞的体内运动和激活。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Lewis rats rats, delayed-type hypersensitivity (DTH) model
Dosage:	100 μg/kg
Administration:	Subcutaneous injection, once
Result:	Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.

体内研究

Dalazatide (ShK-186) (100 μg/kg; s.c.; once) TFA 在大鼠中抑制延迟型超敏反应，并抑制 Tem 细胞的体内运动和激活。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Lewis rats rats, delayed-type hypersensitivity (DTH) model
Dosage:	100 μg/kg
Administration:	Subcutaneous injection, once
Result:	Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.