Cagrilintide acetate|西域试剂

Cagrilintide acetate,99.81%

产品编号：Bellancom-P3462A| 分子式：C₁₉₆H₃₁₆N₅₄O₆₁S₂| 分子量：4469.06

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货号	价格	库存与货期
Bellancom-P3462A	￥1500.00	杭州北京（现货）
Bellancom-P3462A	￥4500.00	杭州北京（现货）
Bellancom-P3462A	￥7200.00	杭州北京（现货）

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Cagrilintide acetate

产品介绍

Cagrilintide acetate 是一种非选择性的 AMYR/CTR 激动剂和长效酰化淀粉酶类似物。Cagrilintide acetate 以剂量依赖的方式导致食物摄入减少和体重明显下降。Cagrilintide acetate 可用于肥胖症的研究。

生物活性

Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies.

体外研究

体内研究

Cagrilintide acetate (compound 23) (0.1, 1, 3, 10, 30 nmol/kg; s.c.single) reduces food intake in the rat.
Cagrilintide acetate (10 nmol/kg; i.v. or s.c.; single) shows good pharmacokinetic parameters.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague Dawley male rats (12-week-old; ~400 g)
Dosage:	0.1, 1, 3, 10, 30 nmol/kg
Administration:	Subcutaneous injection; single
Result:	Reduced food intake in the rat for several days at doses in the range of 1-10 nmol/kg.

Animal Model:	Sprague Dawley male rats (12-week-old; ~400 g)
Dosage:	10 nmol/kg
Administration:	Intravenous injection or subcutaneous injection; single
Result:	Showed good pharmacokinetic parameters with T_1/2 of 20, 27 h for i.v. and s.c., respectively.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague Dawley male rats (12-week-old; ~400 g)
Dosage:	0.1, 1, 3, 10, 30 nmol/kg
Administration:	Subcutaneous injection; single
Result:	Reduced food intake in the rat for several days at doses in the range of 1-10 nmol/kg.

Animal Model:	Sprague Dawley male rats (12-week-old; ~400 g)
Dosage:	10 nmol/kg
Administration:	Intravenous injection or subcutaneous injection; single
Result:	Showed good pharmacokinetic parameters with T_1/2 of 20, 27 h for i.v. and s.c., respectively.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (22.38 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2238 mL	1.1188 mL	2.2376 mL
5 mM	0.0448 mL	0.2238 mL	0.4475 mL
10 mM	0.0224 mL	0.1119 mL	0.2238 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Stored under nitrogen, away from moisture