Saccharopine hydrochloride L-Saccharopine hydrochloride|西域试剂

Saccharopine hydrochloride L-Saccharopine hydrochloride,97.0%

产品编号：Bellancom-W040307B| 分子式：C₁₁H₂₁ClN₂O₆| 分子量：312.75

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货号	价格	库存与货期
Bellancom-W040307B	￥1200.00	杭州北京（现货）
Bellancom-W040307B	￥2000.00	杭州北京（现货）
Bellancom-W040307B	￥4000.00	杭州北京（现货）

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Saccharopine hydrochloride L-Saccharopine hydrochloride

产品介绍

Saccharopine (L-Saccharopine) hydrochloride 是赖氨酸的降解中间体，是一种线粒体毒素。赖氨酸-酮戊二酸还原酶将赖氨酸和 α-酮戊二酸转化为 Saccharopine hydrochloride。糖精脱氢酶将 Saccharopine hydrochloride 氧化为 α-氨基己酸酯半醛和谷氨酸。Saccharopine hydrochloride 通过破坏线粒体稳态而损害发育。

生物活性

Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis.

体外研究

Saccharopine 积累导致线粒体损伤和功能丧失，这是由 C. elegans 中 α-氨基己二酸半醛合酶 (AASS-1) 的糖苷脱氢酶 (SDH) 突变引起的。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Saccharopine 积累可导致 Aass 突变小鼠的线粒体损伤和进行性出生后生长迟缓。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Saccharopine 积累可导致 Aass 突变小鼠的线粒体损伤和进行性出生后生长迟缓。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Oil

溶解性数据

In Vitro:

H₂O : 250 mg/mL (799.36 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1974 mL	15.9872 mL	31.9744 mL
5 mM	0.6395 mL	3.1974 mL	6.3949 mL
10 mM	0.3197 mL	1.5987 mL	3.1974 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献