Dasiglucagon acetate|西域试剂

Dasiglucagon acetate,99.92%

产品编号：Bellancom-P3469A| 分子式：C₁₅₄H₂₂₆N₃₈O₅₂| 分子量：3441.67

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货号	价格	库存与货期
Bellancom-P3469A	￥900.00	杭州北京（现货）
Bellancom-P3469A	￥2300.00	杭州北京（现货）
Bellancom-P3469A	￥3700.00	杭州北京（现货）
Bellancom-P3469A	￥7400.00	杭州北京（现货）

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Dasiglucagon acetate

产品介绍

Dasiglucagon acetate 是一种人胰高血糖素类似物，可以增加血浆葡萄糖。Dasiglucagon 可用于低血糖症的研究。

生物活性

Dasiglucagon acetate is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research.

体外研究

体内研究

Dasiglucagon PK profile shows a dose-dependent and rapid increase in plasma levels.

		Dasiglucagon dose
	0.1 mg	0.3 mg	0.6 mg	1.0 mg
N	5	16	16	16
AUC_0–30min (pmol*h/L)	99.4 (32.0)	302 (78.9)	444 (163)	884 (307)
AUC_0–360min (pmol*h/L)	451 (123)	1360 (166)	1630 (368)	4800 (697)
AUC_0–inf (pmol*h/L)	451 (123)	1360 (166)	2640 (365)	4810 (696)
C_max (pmol/L)	334 (113)	976 (208)	1570 (445)	2800 (767)
t_max (h)	0.50 (0.5-0.6)	0.63 (0.3-0.8)	0.58 (0.5-1.7)	0.63 (0.3-0.8)
t_1/2 (h)	0.43 (0.07)	0.43 (0.07)	0.49 (0.14)	0.54 (0.17)

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Dasiglucagon PK profile shows a dose-dependent and rapid increase in plasma levels.

		Dasiglucagon dose
	0.1 mg	0.3 mg	0.6 mg	1.0 mg
N	5	16	16	16
AUC_0–30min (pmol*h/L)	99.4 (32.0)	302 (78.9)	444 (163)	884 (307)
AUC_0–360min (pmol*h/L)	451 (123)	1360 (166)	1630 (368)	4800 (697)
AUC_0–inf (pmol*h/L)	451 (123)	1360 (166)	2640 (365)	4810 (696)
C_max (pmol/L)	334 (113)	976 (208)	1570 (445)	2800 (767)
t_max (h)	0.50 (0.5-0.6)	0.63 (0.3-0.8)	0.58 (0.5-1.7)	0.63 (0.3-0.8)
t_1/2 (h)	0.43 (0.07)	0.43 (0.07)	0.49 (0.14)	0.54 (0.17)

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 16.67 mg/mL (4.84 mM; ultrasonic and adjust pH to 3 with HCl)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2906 mL	1.4528 mL	2.9056 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen