Vasonatrin Peptide (VNP) (TFA)|西域试剂

Vasonatrin Peptide (VNP) (TFA),98.79%

产品编号：Bellancom-P1556A| 分子式：C₁₂₆H₁₉₉N₃₆O₃₈S₃F₃| 分子量：2979.39

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货号	价格	库存与货期
Bellancom-P1556A	￥2000.00	杭州北京（现货）
Bellancom-P1556A	￥3600.00	杭州北京（现货）
Bellancom-P1556A	￥9900.00	杭州北京（现货）

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Vasonatrin Peptide (VNP) (TFA)

产品介绍

Vasonatrin Peptide (VNP) TFA 是心钠素 (ANP) 和C型利钠肽 (CNP) 的嵌合体。Vasonatrin Peptide TFA 具有 CNP 的静脉扩张作用、ANP 的利尿作用以及与 ANP 或 CNP 无关的独特的动脉血管扩张作用。Vasonatrin Peptide TFA 通过 cGMP-PKG 信号通路抑制内质网应激对糖尿病心脏缺血再灌注损伤的保护作用。

生物活性

Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway.

体外研究

Vasonatrin Peptide (VNP) markedly enhances adiponectin mRNA expression, as well as protein secretion, however, suppresses IL-6 production in mature adipocytes. In addition, VNP significantly increases the intracellular levels of cGMP. The effects of VNP are mimicked by 8-br-cGMP, whereas inhibits by HS-142-1, or KT-5823.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats
Dosage:	100 μg/kg
Administration:	I.v. ; 10 min before reperfusion
Result:	Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/d_tmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).

体内研究

Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats
Dosage:	100 μg/kg
Administration:	I.v. ; 10 min before reperfusion
Result:	Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/d_tmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).