PDE10A-IN-2 hydrochloride|西域试剂

PDE10A-IN-2 hydrochloride,98.43%

产品编号：Bellancom-131973| 分子式：C₃₃H₃₈Cl₃N₅O| 分子量：627.05

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货号	价格	库存与货期
Bellancom-131973	￥3500.00	杭州北京（现货）
Bellancom-131973	￥6000.00	杭州北京（现货）
Bellancom-131973	￥12500.00	杭州北京（现货）

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PDE10A-IN-2 hydrochloride

产品介绍

PDE10A-IN-2 hydrochloride 是一种有效的，高选择性，具有口服活性的磷酸二酯酶 10A (PDE10A) 的抑制剂，IC₅₀ 为 2.8 nM。PDE10A-IN-2 hydrochloride 对其他 PDE 亚型显示出大于 3500 倍的选择性，并可用于肺动脉高压 (PAH) 的研究。

生物活性

PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC₅₀ of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can be used for pulmonary arterial hypertension (PAH) research.

体外研究

体内研究

PDE10A-IN-2 hydrochloride (compound 14 3HCL; 2.5 mg/kg; oral administration; daily; for 3 weeks) treatment decreases the typical symptoms of PAH in rats.
In Sprague-Dawley rats, the pharmacokinetic study of PDE10A-IN-2 hydrochloride (compound 14 3HCL; 10 mg/kg) shows the oral bioavailability up to ∼50%, and the T_1/2 is 5.2 hours (p.o.), and the C_max is 272 ng/mL.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wister rats (6 weeks, 160-180 g) injected with Monocrotaline
Dosage:	2.5 mg/kg
Administration:	Oral administration; daily; for 3 weeks
Result:	Decreased symptoms of the pulmonary arterial hypertension (PAH) rats.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wister rats (6 weeks, 160-180 g) injected with Monocrotaline
Dosage:	2.5 mg/kg
Administration:	Oral administration; daily; for 3 weeks
Result:	Decreased symptoms of the pulmonary arterial hypertension (PAH) rats.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (159.48 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5948 mL	7.9738 mL	15.9477 mL
5 mM	0.3190 mL	1.5948 mL	3.1895 mL
10 mM	0.1595 mL	0.7974 mL	1.5948 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献