AA-T3A-C12|西域试剂

AA-T3A-C12,98.0%

产品编号：Bellancom-148859| 分子式：C₆₅H₁₂₆N₄O₆| 分子量：1059.72

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-148859	￥2900.00	杭州北京（现货）
Bellancom-148859	￥4700.00	杭州北京（现货）
Bellancom-148859	￥9500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品介绍

AA-T3A-C12 是一种茴香酰胺配体-栓系类脂质 (AA-lipidoid)。AA-T3A-C12 介导大量 RNA 递送和活化的成纤维细胞的转染。

生物活性

AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts.

体外研究

AA-T3A-C12/siRNA LNP 可增强 TGF-β 刺激的 3T3 成纤维细胞对 siRNA LNP 的摄取。
AA-T3A-C12 LNP 可在活化的成纤维细胞中实现较强的基因敲低。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

AA-T3A-C12/siHSP47 LNP (siRNA 剂量为 5 μg/小鼠，静脉注射，每周两次，持续 2 周) 显着下调纤维化小鼠中的 HSP47 表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CCl₄-induced fibrotic mice
Dosage:	siRNA dose of 5 μg/mouse
Administration:	i.v., twice weekly for 2 weeks
Result:	led to a 65% knockdown of HSP47 (in liver) compared to PBS treatment.

体内研究

AA-T3A-C12/siHSP47 LNP (siRNA 剂量为 5 μg/小鼠，静脉注射，每周两次，持续 2 周) 显着下调纤维化小鼠中的 HSP47 表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CCl₄-induced fibrotic mice
Dosage:	siRNA dose of 5 μg/mouse
Administration:	i.v., twice weekly for 2 weeks
Result:	led to a 65% knockdown of HSP47 (in liver) compared to PBS treatment.