Ac-DEVD-CMK TFA Caspase-3 Inhibitor III TFA|西域试剂

Ac-DEVD-CMK TFA Caspase-3 Inhibitor III TFA,99.07%

产品编号：Bellancom-P0034A| 分子式：C₂₃H₃₂ClF₃N₄O₁₃| 分子量：664.97

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P0034A		￥1000.00	杭州北京（现货）
Bellancom-P0034A		￥4000.00	杭州北京（现货）

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Ac-DEVD-CMK TFA Caspase-3 Inhibitor III TFA

产品介绍

Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA 是一种选择性且不可逆的 caspase-3 抑制剂。Ac-DEVD-CMK TFA 显着抑制由高水平葡萄糖或 3,20-dibenzoate (IDB; HY-137295) 诱导的凋亡。Ac-DEVD-CMK TFA 可以用于多种实验方法以抑制细胞凋亡。

生物活性

Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis.

体外研究

Ac-DEVD-CMK TFA (100 μM; 24 h) 抑制 IDB 诱导的细胞凋亡。
Ac-DEVD-CMK TFA (10 μM; 36 h) 抑制人咽鳞癌 FaDu 和 Detroit 562 细胞系中柠檬酸盐 (10 mM) 诱导的 p21 裂解和 G2/M 积累^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:	FaDu and Detroit 562 cell
Concentration:	10 μM; with 10 mM citrate
Incubation Time:	36 h
Result:	Inhibited citrate to induce p21 cleavage.

体内研究
(In Vivo)

Ac-DEVD-CMK TFA (Caspase-3 Inhibitor III；25 mg/kg；腹腔注射；单剂量；APAP 后 3 小时) 显着减弱对乙酰氨基酚 (APAP；HY-66005) 诱导的肝损伤 (AILI)^[5]。
Ac-DEVD-CMK TFA (25 mg/kg；ip；单剂量) 显著减轻易感 Sdc1^−/− 小鼠中 APAP 诱导的肝损伤 (AILI)^[6]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sdc1^−/− mice induced by APAP^[6]
Dosage:	25 mg/kg
Administration:	IP; single dose, 3 hours post-APAP
Result:	Inhibited GSK‐3β or caspase‐3 activity to mitigate liver damage.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sdc1^−/− mice induced by APAP^[6]
Dosage:	25 mg/kg
Administration:	IP; single dose, 3 hours post-APAP
Result:	Inhibited GSK‐3β or caspase‐3 activity to mitigate liver damage.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sdc1^−/− mice induced by APAP^[6]
Dosage:	25 mg/kg
Administration:	IP; single dose, 3 hours post-APAP
Result:	Inhibited GSK‐3β or caspase‐3 activity to mitigate liver damage.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (75.19 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5038 mL	7.5191 mL	15.0383 mL
5 mM	0.3008 mL	1.5038 mL	3.0077 mL
10 mM	0.1504 mL	0.7519 mL	1.5038 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen