Epitalon TFA Epithalon TFA; Epithalamin TFA|西域试剂

Epitalon TFA Epithalon TFA; Epithalamin TFA,98.72%

产品编号：Bellancom-P1149A| 分子式：C₁₆H₂₃F₃N₄O₁₁| 分子量：504.37

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P1149A	￥650.00	杭州北京（现货）
Bellancom-P1149A	￥1950.00	杭州北京（现货）
Bellancom-P1149A	￥3500.00	杭州北京（现货）
Bellancom-P1149A	￥7500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Epitalon TFA Epithalon TFA; Epithalamin TFA

产品介绍

Epitalon TFA 是一种抗衰老剂和端粒酶激活剂。Epitalon TFA 对小鼠自发性肿瘤的发展具有抑制作用，具有 geroprotective 作用，通过鼻内给药可增加神经元活性。Epitalon TFA 可用于癌症，衰老和色素性视网膜炎。

生物活性

Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa.

体外研究

Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Epitalon TFA increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys. At the same time, Epitalon prolongs the functional integrity of the eye retina in Campbell rats with hereditary Retinitis Pigmentosa and improves the visual functions in patients with pigmental retinal degeneration.
Epitalon TFA (subcutaneous injection; 1.0 µg/mouse (30-40 µg/kg); 5 consecutive days every month; 3-12 months) does not influence food consumption, body weight or mean life span of mice. However, Epitalon slows down the age-related switching-off of estrous function and decreased the frequency of chromosome aberrations in bone marrow cells (by 17.1%). Epitalon increased by 13.3% the life span of the last 10% of the survivors in comparison with the control group in Swiss-derived SHR mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss-derived SHR mice^[4]
Dosage:	1.0 µg/mouse (∼30-40 µg/kg)
Administration:	Subcutaneous injection; 1.0 µg/mouse (∼30-40 µg/kg) ; 5 consecutive days every month; 3-12 months
Result:	Significantly decreased the age-associated increase in chromosome aberrations after long-term treatment.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss-derived SHR mice^[4]
Dosage:	1.0 µg/mouse (∼30-40 µg/kg)
Administration:	Subcutaneous injection; 1.0 µg/mouse (∼30-40 µg/kg) ; 5 consecutive days every month; 3-12 months
Result:	Significantly decreased the age-associated increase in chromosome aberrations after long-term treatment.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (495.67 mM; Need ultrasonic)

H₂O : 100 mg/mL (198.27 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9827 mL	9.9134 mL	19.8267 mL
5 mM	0.3965 mL	1.9827 mL	3.9653 mL
10 mM	0.1983 mL	0.9913 mL	1.9827 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (99.13 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.12 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.12 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.12 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。