GSK2983559|西域试剂

GSK2983559,99.24%

产品编号：Bellancom-112038A| 分子式：C₂₁H₂₈CaN₄O₁₀PS₂⁺| 分子量：611.61

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货号	价格	库存与货期
Bellancom-112038A	￥2500.00	杭州北京（现货）
Bellancom-112038A	￥4100.00	杭州北京（现货）
Bellancom-112038A	￥8200.00	杭州北京（现货）
Bellancom-112038A	￥15200.00	杭州北京（现货）

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GSK2983559

产品介绍

GSK2983559 (compound 3) 是一种具有口服活性且高效的受体相互作用蛋白 2 (RIP2) 激酶抑制剂。GSK2983559 在体内和人类炎症性肠病外植体样本中可阻断多种促炎细胞因子反应活性。

生物活性

GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

体外研究

GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	THP-1 cells
Concentration:	1-1024 nM
Incubation Time:	2 hours
Result:	Inhibited IL-8 production with an IC₅₀ of 1.34 nM.

体内研究
(In Vivo)

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (female) injected with MDP (100 μg)
Dosage:	3 and 10 mg/kg
Administration:	Oral gavage; 3 and 10 mg/kg; once
Result:	Suppressed serum IL-6 levels in a dose-dependent manner.

体内研究

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (female) injected with MDP (100 μg)
Dosage:	3 and 10 mg/kg
Administration:	Oral gavage; 3 and 10 mg/kg; once
Result:	Suppressed serum IL-6 levels in a dose-dependent manner.

体内研究

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (female) injected with MDP (100 μg)
Dosage:	3 and 10 mg/kg
Administration:	Oral gavage; 3 and 10 mg/kg; once
Result:	Suppressed serum IL-6 levels in a dose-dependent manner.

性状

Solid

溶解性数据

In Vitro:

H₂O : 2 mg/mL (3.27 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble or slightly soluble)

DMF : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble)

Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

*GSK2983559 is usually formulated as a suspension.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6350 mL	8.1751 mL	16.3503 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献