Nadunolimab
| 产品介绍 | Nadunolimab 是一种靶向 IL1RAP 的人 IgG1 单克隆抗体。Nadunolimab 阻断 IL-1α 和 IL-1β 信号并触发抗体依赖性细胞毒性。Nadunolimab 可用于癌症的研究。 | ||||||||
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| 生物活性 | Nadunolimab is a human monoclonal IgG1 antibody targeting IL1RAP. Nadunolimab blocks IL-1α and IL-1β signaling and triggering antibody-dependent cellular cytotoxicity. Nadunolimab can be used in research of cancer. | ||||||||
| 体外研究 |
Nadunolimab (20 µg/mL; 30 min and 1 h; A549 cells and BxPC3 cells) reduces IL-1α-induced release of pro-infamma tory cytokines and chemokines, including IL-1β, IL-6 TNF-α and MIP-1α, and CXCL1. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
Nadunolimab (10 mg/kg; i.p.; twice on day 1 and thereafter twice weekly; nude BALB/c mice with LU2503 or MC38 tumors) improves the anti‑tumor efficacy of chemotherapy and blocks both murine IL-1α and IL-1β signaling. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究 |
Nadunolimab (10 mg/kg; i.p.; twice on day 1 and thereafter twice weekly; nude BALB/c mice with LU2503 or MC38 tumors) improves the anti‑tumor efficacy of chemotherapy and blocks both murine IL-1α and IL-1β signaling. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 性状 | Liquid | ||||||||
| 溶解性数据 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. | ||||||||
| 参考文献 |
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