JAK-IN-5 hydrochloride|西域试剂

JAK-IN-5 hydrochloride,99.54%

产品编号：Bellancom-111471A| 分子式：C₂₇H₃₂ClFN₆O| 分子量：511.03

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货号	价格	库存与货期
Bellancom-111471A	￥4500.00	杭州北京（现货）
Bellancom-111471A	￥8000.00	杭州北京（现货）
Bellancom-111471A	￥16500.00	杭州北京（现货）
Bellancom-111471A	￥25500.00	杭州北京（现货）

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JAK-IN-5 hydrochloride

产品介绍

JAK-IN-5 hydrochloride 是 JAK 的抑制剂，来自专利US20170121327A1，化合物实例 283。

生物活性

JAK-IN-5 hydrochloride is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.

体外研究

体内研究

JAK-IN-5 hydrochloride (compound 1) (oral aspirate, 0.5 mg/mL, 50 μL ) inhibits STAT6 phosphorylation by 60% in IL-13-induced in lung tissue in a mouse model of pSTAT6 induction.
JAK-IN-5 hydrochloride (compound 1) (oral aspirate, 0.1-1.0 mg/mL, 50 μL) inhibits 88% of BALF eosinophils in male C57 mice model of Alternaria alternata-induced eosinophilic inflammation of the lung.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (9.78 mM; Need ultrasonic)

H₂O : 0.5 mg/mL (0.98 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9568 mL	9.7842 mL	19.5683 mL
5 mM	0.3914 mL	1.9568 mL	3.9137 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献