BMSpep-57 hydrochloride|西域试剂

BMSpep-57 hydrochloride,99.69%

产品编号：Bellancom-P3143A| 分子式：C₈₉H₁₂₇ClN₂₄O₁₉S| 分子量：1904.63

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P3143A		￥8000.00	杭州北京（现货）

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BMSpep-57 hydrochloride

产品介绍

BMSpep-57 hydrochloride 是一种有效的大环肽类抑制剂，抑制 PD-1/PD-L1 相互作用，IC₅₀ 为 7.68 nM。BMSpep-57 hydrochloride 与 PD-L1 结合，MST 和 SPR 测定表明，K_d 分别为 19 nM 和 19.88 nM。BMSpep-57 hydrochloride 通过增加 PBMC 中 IL-2 的产生促进 T 细胞功能。

生物活性

BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs.

体外研究

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300 nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC₅₀ of 7.68 nM.
BMSpep-57 induced high levels of IL-2 at 1 µM and 500 nM concentrations in SEB-stimulated peripheral blood mononuclear cells.
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture