Lonodelestat TFA POL6014 TFA|西域试剂

Lonodelestat TFA POL6014 TFA,99.86%

产品编号：Bellancom-P3293A| 分子式：C₇₃H₁₁₂F₃N₁₅O₂₁| 分子量：1592.75

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P3293A	￥3000.00	杭州北京（现货）
Bellancom-P3293A	￥4500.00	杭州北京（现货）
Bellancom-P3293A	￥9500.00	杭州北京（现货）
Bellancom-P3293A	￥15200.00	杭州北京（现货）
Bellancom-P3293A	￥24400.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Lonodelestat TFA POL6014 TFA

产品介绍

Lonodelestat TFA (POL6014 TFA) 是有效的、具有口服活性的、选择性的人中性粒细胞弹性蛋白酶(hNE) 的肽类抑制剂。Lonodelestat TFA 具有囊性纤维化 (CF) 研究的潜力 .

生物活性

Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF).

体外研究

体内研究

Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice.
Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (31.39 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.6278 mL	3.1392 mL	6.2784 mL
5 mM	0.1256 mL	0.6278 mL	1.2557 mL
10 mM	0.0628 mL	0.3139 mL	0.6278 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen