Glepaglutide acetate ZP1848 acetate|西域试剂

Glepaglutide acetate ZP1848 acetate,98.06%

产品编号：Bellancom-P2221B| 分子式：C₁₉₉H₃₂₉N₅₃O₅₇| 分子量：4376.13

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货号	价格	库存与货期
Bellancom-P2221B	￥1050.00	杭州北京（现货）
Bellancom-P2221B	￥2600.00	杭州北京（现货）
Bellancom-P2221B	￥4500.00	杭州北京（现货）

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Glepaglutide acetate ZP1848 acetate

产品介绍

Glepaglutide (ZP1848) acetate，一种长效的 GLP-2 类似物，是一种有效的 GLP-2R 激动剂。Glepaglutide acetate 可减少粪便排出量并增加肠道吸收。Glepaglutide acetate 可减轻小肠炎症。Glepaglutide acetate 可用于炎症性肠病 (IBD) 和克罗恩病的研究。

生物活性

Glepaglutide (ZP1848) acetate, a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide acetate reduces faecal output and increases intestinal absorption. Glepaglutide acetate alleviates small intestinal inflammation. Glepaglutide acetate can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease.

体外研究

体内研究

Glepaglutide (ZP1848; 200 和 400 nmol/kg; 皮下注射; 每天两次; 持续 14 天) acetate 对小肠炎症大鼠显示出肠营养的作用。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats with Indomethacin (HY-14397)-induced small intestinal inflammation
Dosage:	200 and 400 nmol/kg
Administration:	Subcutaneousinjection (s.c.), twice a day for 14 days
Result:	Increased plasma citrulline concentration. Increased small intestinal mass. Decreased small intestinal concentrations of the inflammatory marker (AGP and MPO).

体内研究

Glepaglutide (ZP1848; 200 和 400 nmol/kg; 皮下注射; 每天两次; 持续 14 天) acetate 对小肠炎症大鼠显示出肠营养的作用。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats with Indomethacin (HY-14397)-induced small intestinal inflammation
Dosage:	200 and 400 nmol/kg
Administration:	Subcutaneousinjection (s.c.), twice a day for 14 days
Result:	Increased plasma citrulline concentration. Increased small intestinal mass. Decreased small intestinal concentrations of the inflammatory marker (AGP and MPO).

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (22.85 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2285 mL	1.1426 mL	2.2851 mL
5 mM	0.0457 mL	0.2285 mL	0.4570 mL
10 mM	0.0229 mL	0.1143 mL	0.2285 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen