Cecropin A TFA 抗菌肽三氟醋酸盐|西域试剂

Cecropin A TFA 抗菌肽三氟醋酸盐,99.00%

产品编号：Bellancom-P1539A| 分子式：C₁₈₆H₃₁₄N₅₃O₄₈F₃| 分子量：4117.80

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货号	价格	库存与货期
Bellancom-P1539A	￥1900.00	杭州北京（现货）
Bellancom-P1539A	￥4900.00	杭州北京（现货）
Bellancom-P1539A	￥7400.00	杭州北京（现货）

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Cecropin A TFA 抗菌肽三氟醋酸盐

产品介绍

Cecropin A TFA 是由 37 个氨基酸残基构成的线性抗菌肽，从 Hyalaphora cecropia pupae 得到，具有抗菌、抗炎和抗癌作用。

生物活性

Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory and anti-cancer activity.

体外研究

Cecropin A (10, 20, 30, 40 and 50 μM) induces cytotoxicity on HL-60 cells in a dose-dependent manner. Cecropin A induces apoptosis independent of caspase activation.
Cecropin A shows good antibacterial activity against both multidrug-resistant Gram-negative bacteria such as A. baumanii (MDRAB) and multidrug-resistant P. aeruginosa (MDRPA) with IC₅₀s of 0.5-1 μM.
Cecropin A (0.1, 0.25 μM) exhibits anti-inflammatory activities. Cecropin A (25 μM) effectively suppresses the expression of mTNF-α, mIL-1β, and mMIP-2 mRNA and slightly inhibits the expression of mMIP-1 mRNA. Cecropin A also effectively inhibits LPS-induced phosphorylation of ERK, JNK, p38 MAPK, and reduced the expression of COX-2.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 50 mg/mL (12.14 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2428 mL	1.2142 mL	2.4285 mL
5 mM	0.0486 mL	0.2428 mL	0.4857 mL
10 mM	0.0243 mL	0.1214 mL	0.2428 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture