Forigerimod TFA IPP-201101 TFA|西域试剂

Forigerimod TFA IPP-201101 TFA,98.32%

产品编号：Bellancom-105037A| 分子式：C₁₁₉H₁₈₂F₃N₃₄O₃₄PS| 分子量：2752.96

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-105037A	￥1750.00	杭州北京（现货）
Bellancom-105037A	￥5200.00	杭州北京（现货）
Bellancom-105037A	￥8300.00	杭州北京（现货）

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Forigerimod TFA IPP-201101 TFA

产品介绍

Forigerimod TFA (IPP-201101 TFA) 是一种 CD4 T 细胞调节剂。Forigerimod TFA 是 U1 小核核糖核蛋白 70 kDa 的 21 个氨基酸片段，在 Ser140 位点被磷酸化。Forigerimod TFA 可以有效抑制自噬。Forigerimod TFA 可用于系统性红斑狼疮 (SLE) 等自身免疫性疾病的研究。

生物活性

Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) ^[4].

体外研究

体内研究

Forigerimod TFA (P140) (i.v.; 100 μg in 100 μL saline per mouse) 直接作用于分子伴侣介导的自噬，使 MRL/lpr 小鼠免于唾液腺中发生的细胞浸润和自噬缺陷^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MRL/lpr mice^[4]
Dosage:	100 μg in 100 μL saline per mouse
Administration:	Intravenous administration, single
Result:	Corrected the cell content and distribution in MRL/lpr salivary glands. Corrected the defective of autophagy processes in SGs of MRL/lpr mice.

体内研究

Forigerimod TFA (P140) (i.v.; 100 μg in 100 μL saline per mouse) 直接作用于分子伴侣介导的自噬，使 MRL/lpr 小鼠免于唾液腺中发生的细胞浸润和自噬缺陷^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MRL/lpr mice^[4]
Dosage:	100 μg in 100 μL saline per mouse
Administration:	Intravenous administration, single
Result:	Corrected the cell content and distribution in MRL/lpr salivary glands. Corrected the defective of autophagy processes in SGs of MRL/lpr mice.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (36.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.3632 mL	1.8162 mL	3.6325 mL
5 mM	0.0726 mL	0.3632 mL	0.7265 mL
10 mM	0.0363 mL	0.1816 mL	0.3632 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen