Avibactam sodium hydrate 阿维巴坦钠水合物; NXL-104 hydrate|西域试剂

Avibactam sodium hydrate 阿维巴坦钠水合物; NXL-104 hydrate

产品编号：Bellancom-14879B| 分子式：C₇H₁₂N₃NaO₇S| 分子量：305.24

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货号	价格	库存与货期
Bellancom-14879B	￥500.00	杭州北京（现货）
Bellancom-14879B	￥650.00	杭州北京（现货）
Bellancom-14879B	￥950.00	杭州北京（现货）
Bellancom-14879B	￥2600.00	杭州北京（现货）
Bellancom-14879B	￥3800.00	杭州北京（现货）

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Avibactam sodium hydrate 阿维巴坦钠水合物; NXL-104 hydrate

产品介绍

Avibactam sodium (NXL-104) hydrate 是一种共价的、可逆的非 β-内酰胺 β-内酰胺酶抑制剂 (β-lactamase) 抑制剂，抑制 β-lactamase TEM-1 和 CTX-M-15，IC₅₀ 分别为 8 nM 和 5 nM。

生物活性

Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively.

体外研究

Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases.
Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 bla_KPC-2 positive and 1 of bla_OXA-232 positive Klebsiella pneumonia growth with MIC₅₀ and MIC₉₀ for both 8 mg/L^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model.
Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model^[4]
Dosage:	0.375 mg/g in combination with Ceftazidime
Administration:	Subcutaneous injection, 4 h post infection and given every 8 h for 10 days
Result:	70% of infection group mice died within 4 days, and all mice in the PBS group died within 13 days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8 h, whereas 100% of mice in this group died within 4 days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model^[4]
Dosage:	0.375 mg/g in combination with Ceftazidime
Administration:	Subcutaneous injection, 4 h post infection and given every 8 h for 10 days
Result:	70% of infection group mice died within 4 days, and all mice in the PBS group died within 13 days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8 h, whereas 100% of mice in this group died within 4 days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 200 mg/mL (655.22 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2761 mL	16.3806 mL	32.7611 mL
5 mM	0.6552 mL	3.2761 mL	6.5522 mL
10 mM	0.3276 mL	1.6381 mL	3.2761 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶