INCB059872 dihydrochloride|西域试剂

INCB059872 dihydrochloride,98.77%

产品编号：Bellancom-141677A| 分子式：C₂₃H₃₆Cl₂N₂O₃| 分子量：459.45

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-141677A	￥3500.00	杭州北京（现货）
Bellancom-141677A	￥9500.00	杭州北京（现货）
Bellancom-141677A	￥15000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

INCB059872 dihydrochloride

产品介绍

INCB059872 dihydrochloride 是一种有效、具有口服活性，选择性和不可逆的赖氨酸特异性去甲基化酶1 (LSD1) 抑制剂。INCB059872 dihydrochloride 可用于髓系白血病的研究。

生物活性

INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia.

体外研究

INCB059872 (25 nM; 48 小时; 293T 细胞) dihydrochloride 增加增强子活性和基因表达。
INCB059872 (25 nM; 48 小时; THP-1 细胞) dihydrochloride 使 THP-1 在一个细胞倍增时间内或大约 3 天内显示出生长缺陷。
INCB059872 (THP-1 细胞) dihydrochloride 调节 PRO-seq 分析鉴定基因和增强子。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	293T cells
Concentration:	250 nM
Incubation Time:	48 hours
Result:	Increased enhancer activity and gene expression.

体内研究
(In Vivo)

INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 天; C57BL/6J 小鼠) dihydrochloride 使单细胞 RNA-seq 显示骨髓祖细胞群。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice
Dosage:	10 mg/kg
Administration:	p.o.; 0, 4, or 6 days
Result:	Single-cell RNA-seq revealed changes in bone marrow progenitor populations.

体内研究

INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 天; C57BL/6J 小鼠) dihydrochloride 使单细胞 RNA-seq 显示骨髓祖细胞群。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice
Dosage:	10 mg/kg
Administration:	p.o.; 0, 4, or 6 days
Result:	Single-cell RNA-seq revealed changes in bone marrow progenitor populations.

体内研究

INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 天; C57BL/6J 小鼠) dihydrochloride 使单细胞 RNA-seq 显示骨髓祖细胞群。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice
Dosage:	10 mg/kg
Administration:	p.o.; 0, 4, or 6 days
Result:	Single-cell RNA-seq revealed changes in bone marrow progenitor populations.

性状

Solid

溶解性数据

In Vitro:

DMSO : 3.57 mg/mL (7.77 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1765 mL	10.8826 mL	21.7652 mL
5 mM	0.4353 mL	2.1765 mL	4.3530 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献