HIV-1 inhibitor-8|西域试剂

HIV-1 inhibitor-8,98.03%

产品编号：Bellancom-132291| 分子式：C₂₅H₂₁N₅OS| 分子量：439.53

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-132291	￥3000.00	杭州北京（现货）
Bellancom-132291	￥4500.00	杭州北京（现货）
Bellancom-132291	￥9500.00	杭州北京（现货）
Bellancom-132291	￥15000.00	杭州北京（现货）

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HIV-1 inhibitor-8

产品介绍

HIV-1 inhibitor-8 是一种具有口服活性、低毒和有效的 HIV -1 非核苷逆转录酶抑制剂 (NNRTI)。HIV-1 inhibitor-8 对各种 HIV -1 菌株产生有效的抗病毒活性 (EC₅₀=4.44~54.5 nM)。HIV-1 inhibitor-8 对 WT HIV-1 逆转录酶的 IC₅₀ 为 0.081 μM。

生物活性

HIV-1 inhibitor-8 is an orally active, low-toxicity and potent HIV‑1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC₅₀=4.44~54.5 nM) against various HIV‑1 strains. The IC₅₀ of HIV-1 inhibitor-8 against WT HIV-1 reverse transcriptase is 0.081 μM.

体外研究

HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC₅₀=4.44~54.5 nM) against various HIV-1 strains and improves resistance profiles (RF = 0.5~5.6). HIV-1 inhibitor-8 exhibits reduces cytotoxicity (CC₅₀=284 μM) and higher SI values (SI = 5210~63992). HIV-1 inhibitor-8 displays better solubility (sol. =12.8 μg/mL) and no significant inhibition of the main CYP enzymes. HIV-1 inhibitor-8 displays an extremely low hERG inhibition with an IC₅₀ value of 19.84 μM in CHO-hERG cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

HIV-1 inhibitor-8 (2 mg/kg; i.v.) shows a favorable mean CL, volume of distribution and a long terminal half-life.
HIV-1 inhibitor-8 (20 mg/kg; p.o.) absorption reaches maximum at 0.25 hours with a plasma concentration value of 16.6 ng/mL and the mean residence time is 2.90 hours.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley (SD) rat
Dosage:	2 mg/kg
Administration:	I.v.
Result:	Showed a favorable mean CL, volume of distribution and a long terminal half-life.

Animal Model:	Sprague-Dawley (SD) rat
Dosage:	20 mg/kg
Administration:	P.o.
Result:	Absorption reached maximum at 0.25 hours with a plasma concentration value of 16.6 ng/mL and the mean residence time was 2.90 hours.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley (SD) rat
Dosage:	2 mg/kg
Administration:	I.v.
Result:	Showed a favorable mean CL, volume of distribution and a long terminal half-life.

Animal Model:	Sprague-Dawley (SD) rat
Dosage:	20 mg/kg
Administration:	P.o.
Result:	Absorption reached maximum at 0.25 hours with a plasma concentration value of 16.6 ng/mL and the mean residence time was 2.90 hours.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (113.76 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2752 mL	11.3758 mL	22.7516 mL
5 mM	0.4550 mL	2.2752 mL	4.5503 mL
10 mM	0.2275 mL	1.1376 mL	2.2752 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式